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The extraordinary case of the Guevedoces

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Catherine and his cousin Carla, Guevedoces in the Dominican Republic

Catherine and his cousin Carla, Guevedoces in the Dominican Republic

The discovery of a small community in the Dominican Republic, where some males are born looking like girls and only grow penises at puberty, has led to the development of a blockbuster drug that has helped millions of people, writes Michael Mosley.

Johnny lives in a small town in the Dominican Republic where he, and others like him, are known as “Guevedoces”, which effectively translates as “penis at twelve”.

We came across Johnny when we were filming for a new BBC Two series Countdown to Life, which looks at how we develop in the womb and how those changes, normal and abnormal, impact us later in life.

Like the other Guevedoces, Johnny was brought up as a girl because he had no visible testes or penis and what appeared to be a vagina. It is only when he approached puberty that his penis grew and testicles descended.

Johnny, once known as Felicita, remembers going to school in a little red dress, though he says he was never happy doing girl things.

“I never liked to dress as a girl and when they bought me toys for girls I never bothered playing with them – when I saw a group of boys I would stop to play ball with them.”

When he became obviously male he was taunted at school, and responded with his fists.

“They used to say I was a devil, nasty things, bad words and I had no choice but to fight them because they were crossing the line.”

We also filmed with Carla, who at the seven is on the brink of changing into Carlos. His mother has seen the change coming for quite a while.

“When she turned five I noticed that whenever she saw one of her male friends she wanted to fight with him. Her muscles and chest began growing. You could see she was going to be a boy. I love her however she is. Girl or boy, it makes no difference.”

Child on swing

 

 

So why does it happen? Well, one of the first people to study this unusual condition was Dr Julianne Imperato-McGinley, from Cornell Medical College in New York. In the 1970s she made her way to this remote part of the Dominican Republic, drawn by extraordinary reports of girls turning into boys.

When she got there she found the rumours were true. She did lots of studies on the Guevedoces (including what must have been rather painful biopsies of their testicles) before finally unravelling the mystery of what was going on.

When you are conceived you normally have a pair of X chromosomes if you are to become a girl and a set of XY chromosomes if you are destined to be male.

For the first weeks of life in womb you are neither, though in both sexes nipples start to grow.

Then, around eight weeks after conception, the sex hormones kick in. If you’re genetically male the Y chromosome instructs your gonads to become testicles and sends testosterone to a structure called the tubercle, where it is converted into a more potent hormone called dihydro-testosterone This in turn transforms the tubercle into a penis. If you’re female and you don’t make dihydro-testosterone then your tubercle becomes a clitoris.

Foetus at 12 weeks

When Imperato-McGinley investigated the Guevedoces she discovered the reason they don’t have male genitalia when they are born is because they are deficient in an enzyme called 5-alpha-reductase, which normally converts testosterone into dihydro-testosterone.

This deficiency seems to be a genetic condition, quite common in this part of the Dominican Republic, but vanishingly rare elsewhere. So the boys, despite having an XY chromosome, appear female when they are born. At puberty, like other boys, they get a second surge of testosterone. This time the body does respond and they sprout muscles, testes and a penis.

Imperato-McGinley’s thorough medical investigations showed that in most cases their new, male equipment seems to work fine and that most Guevedoces live out their lives as men, though some go through an operation and remain female.

Another thing that Imperato-McGinley discovered, which would have profound implications for many men around the world, was that the Guevedoces tend to have small prostates.

This observation, made in 1974, was picked up by Roy Vagelos, head of research at the multinational pharmaceutical giant, Merck. He thought this was extremely interesting and set in progress research which led to the development of what has become a best-selling drug, finasteride, which blocks the action of 5-alpha-reductase, mimicking the lack of dihydro-testosterone seen in the Guevedoces.

My wife, who is a GP, routinely prescribes finasteride as it is an effective way to treat benign enlargement of the prostate, a real curse for many men as they get older. Finasteride is also used to treat male pattern baldness.

A final interesting observation that Imperato-McGinley made was that these boys, despite being brought up as girls, almost all showed strong heterosexual preferences. She concluded in her seminal paper that hormones in the womb matter more than rearing when it comes to your sexual orientation.

This is still a controversial topic and one I explore later in the film when I meet Mati, who decided from the earliest age that though “he” looked like a boy, Mati was really a girl.

As for Johnny, since he developed male genitalia he has had a number of short term girlfriends, but he is still looking for love. “I’d like to get married and have children, a partner who will stand by me through good and bad,” he sighs wistfully.

Complete Article HERE!

Hey, Where’s My Big “O”?

Name: BJ
Gender: Female
Age: 23
Location: PA
I’ve been sexually active for several years now and have yet to reach an orgasm. Oral sex, intercourse nor masturbation have been effective. Is there something wrong with me, what might help?

I’d be very much surprised if there was actually something physically wrong with you. But you clearly have some difficulty letting go. And simply put, an orgasm is letting go of built up sexual tension.the big O

Lot of preorgasmic women don’t feel entitled to an orgasm, for one reason or another. Other women are simply unversed on how to make the big “O” happen in their own fine self. Sometimes it’s a combination of both resistance and a lack of know how.

I once had a client, a woman in her late 30’s, the mother of three and a devote Catholic. She was preorgasmic too. Her big stumbling block was fear. You got it; fear of having an orgasm. She had heard from other women over the years how powerful orgasms were and how much fun they were. My client somehow got it in her head that if she were to ever let go and give up that long-awaited screamin’ meme, her entire world would collapse. She’d become a sex addict, neglect her children, divorce her husband and turn her back on God…the whole enchilada.

With that kind of mindset, this little lady wasn’t gonna let herself cum no how.

the big O 2I had to reassure her that, as delightful as orgasms are, they are not like crack cocaine. I told her there was no chance that she’d fly to pieces as a mother, wife and friend of Jesus if she were to diddle herself once in a while. I had to keep repeating this over and over till it finally sank in. You talk about hardheaded! In the end, she had her precious orgasm, joined the ranks for the sexually satisfied and lived happily ever after. …Well, I can’t honestly say about the happily ever after part, but she sure did smile a whole lot more afterwards.

Back to you BJ, I don’t suppose there’s any way you could have one of your gal-pals show you how it’s done, is there? The reason I ask is most guys learn how to choke the chicken by watching, or being instructed by another guy. Us men folk are really good about doin that for one another. Women, on the other hand, don’t seem to do this for one another as much. Which is a freakin’ pity, if ya ask me.

If you can’t (or won’t) get a pal to show you around proper pussy pleasuring, I have another suggestion for you. Mozie on over to DR DICK’S HOW TO VIDEO LIBRARY  and check out a swell instructional video. (There’s a link to this marvelous resource in the header.) Do a quick search for “female masturbation” and let the experts show you a thing or two. You’ll be so glad you did.

Another great resource: The Ultimate Guide to Orgasm for Women: How to Become Orgasmic for a Lifetime by the brilliant Mikaya Heart. By the way, you can find a dynamite two-part interview with Mikaya HERE and HERE!ultimate-guide-to-orgasm-for-women-lg

Here are a few tips:

Get in the mood

Relax as much as you can. Whatever that means for you. Take a warm bath or have a glass of wine. Ensure your privacy: turn off the phone, lock the door for privacy from roommates, kids, whoever. Find a comfy position. Most women start out lying on their backs, legs bent and spread apart, with feet on the ground. Remove most or all of your clothing (or as much as your comfortable with).

Explore your body

Run your hands along your body, lingering along areas that are more responsive to touch than others. If you’re able to do it, and you’ve never done it before, you might want to try to look at your genitals in a mirror. Because so many women are raised with negative messages about their bodies, and particularly their genitals, being able to see while you touch can be powerful and surprising. Find and touch your inner and outer labia, your clitoris, your vagina and your perineum.

Touch yourself

Using one or two fingers, rhythmically stroke the different parts of your vulva, paying particular attention to your clitoris and labia. Experiment with different types of pressure, speed and motion. Try placing a finger on either side of the clitoris and stroking up and down, or placing two fingers on the clitoral hood and rubbing in a circular motion.

Experiment

Try different types of touch: stroke, tickle, knead, pinch, or lightly pull your genitals. Try using one or several fingers, the palm of your hand, even your knuckles.

Build up excitement

Learn to hold onto sexual excitement by building up and then reducing or temporarily stopping the stimulation. (Men do this all the time when they jack-off.  It’s called edging.) Pay attention to how your body is responding. It will tell you the particular stroke that feels best and when to pick up or slow down the tempo.

Don’t forget to breathe

Many women hold their breath as they get excited. Be mindful of your breath and learn to play with breathing during arousal. Try to breathe deeply rather than hold your breath. This can help release the sexual energy, rather than fight it.

Moving a little

In addition to often holding our breath, many women tense up and don’t move much at all when wtheye masturbate. This might work for you just fine, but if you haven’t explored movement, it’s worth a try. Moving while you are getting turned on, and moving during orgasm can change the way you experience pleasure in your body. For some women this means rocking their pelvis. For others it means moving their legs or torso side to side. Find what movement works for you and then intentionally start doing it while you masturbate.

Letting go

If your hand gets tired, give yourself a rest, switch hands, or try a vibrator. If you’re on the brink of orgasm, but can’t quite get over the hump, try to become more conscious of your breathing, give yourself extra stimulation: caress your nipples, or try thrusting your other fingers or a dildo in and out of your vagina.

Ride the Wave

As you begin to orgasm, continue the stimulation through the orgasm. Lighten up on the stimulation during the first extremely sensitive moments but keep it going to enjoy those little pleasurable aftershocks. Your first orgasm may feel like a blip or a blast, but the more you practice, the more variety you will experience.

Fantasizing

Sexual fantasy can be a double edged sword when it comes to masturbation. If you have trouble getting yourself in the mood or getting over the top, a hot fantasy may be just the ticket. I often suggest reading erotica to get in the mood. However, when we fantasize some of our attention is taken away from what’s happening in our bodies in the moment. Sometimes what is getting in the way of us enjoying masturbation is that distance from our bodies. It’s good to try everything, but be mindful of whether or not your fantasies are acting as an enhancer or a distraction.

hitachi-magic-wand-2Some final thoughts…
Vibrators take some of the manual labor out of masturbation by providing direct, intense physical stimulation to the clitoris.  check out all the marvelous vibrators we’ve reviewed for you at Dr Dick’s Sex Toy Reviews.

Many women learn to jill-off in the bath or shower. A direct the stream of water on your vulva and clitoris can be a game changer. Vary the pressure, the pulsation, and the temperature. Alternate methods: slide your butt over the drain so your legs are up in the air and your genitals are up under the tub faucet (rather awkward but do-able for some), or use Jacuzzi jets.

Rub against something–a pillow, the corner of some furniture, a washing machine in operation.

Dildos can be a pleasurable accompaniment to clitoral masturbation, as they offer the fullness of penetration and can also stimulate the g-spot.

Write back again, BJ, and let me know how things go. If you’re not successful, I still have a few other tricks up my sleeve.

Good luck

Boys Will Be Boyz

Name: TJ
Gender: Male
Age: 41
Location: ma
ever since i was a teen i have had the hots for my dad. i would walk into the bathroom on him, or his room to seesmoking him naked and to see his dick. i use to love catching him jack off. i loved to see him in his boxers, and would jack off in his boxers. i even would play with him when he was a sleep get him hard and jack myself off. i thought i was over this till he stayed with me over the weekend. he came out of the bathroom in just his boxers. i was only wearing my boxers also. i became hard and excited. the old thought of playing with his cock came back. that night i went into the guest room took out his penis from his boxers and played with it. till it was erect. i then took a pair of his boxers and jacked off in them. i am 41 now should i have out grown this attraction to my dad?? he knows i am gay, we have talked several times about my playing with him but should this attraction continue?? — lost and confused in dads boxers

This is precious, TJ. You’ve been fondlin’ and jerkin’ off your old man for decades, albeit while he “sleeps.” (He’s one hell of a deep sleeper, huh?) He knows all about you, your attraction to him and your late night play sessions with his cock and underwear. But he still comes for a visit. And predictably, you set upon him again in his sleep. How may more incredible things could you possibly add to a single paragraph?

And all you want to know is, is it odd that you continue to behave like this with your father and continue to have this attraction to him now that you’re 41 years old. AMAZING! Odd? Yeah, I’ll say it’s odd!

Where to begin? Oh skip it! If you and your dad (now somewhere in his late 60’s or even 70’s) are still playing at this little game it must be pretty harmless by this time.

Your behavior and attraction continue because you feed it, darling. No big mystery there.

Name: Alan
Gender: Male
Age: 41
Location: Victoria
I find it takes me for ever to jack off even watching videos it can take 40 minutes an when I do shoot it is only a small amount.

nipplesYou don’t say, Alan! I’ve never heard that question before. No wait, that’s baloney. I’ve heard and written extensively about this very issue.

Look to your right. See the CATEGORY pull down menu in the sidebar? EXCELLENT! Now search for the terms: “Ejaculate” and “Ejaculation Concerns” and “Cum.”  Between these categories you will find the answers you are looking for.

Here’s a tip: you’ll also want to check out what I’ve had to say about “Kegels.” You’re gonna want to know all about these handy-dandy exercises to tone up your PC muscle. Both men and women need to attend to their PC muscle. Not sure what the fuck I’m talking about. Not to worry. You have some fun reading and listening ahead of you.

Good luck

What’s a mother to do?

What we have here is an exchange I had with a woman and while I don’t know anything about her, not even her name, I can make some inferences. If I had to guess, she’s in her 40’s. She’s married and has kids.

You must talk to a lot of women in your practice and hear from a lot of women through your advice site. What would you say are the main sexual concerns of women over the age of 40?

Research shows that approximately 40% of women experience sexual problems. But a 2008 study out of Harvard suggests that only a few — 12% — are concerned enough with these issues to do anything about them. I find that not only surprising, but shocking! That suggests to me that sexual wellbeing is not a high priority for a good number of women.  What a bummer!sexual-Frustration

Low libido, diminished arousal, difficulties with orgasm, pain with sex or body image concerns all play a part. A lot of this is directly connected with having an ineffectual partner. I mean, I’d give up sex too if I was consistently frustrated and unfulfilled. But what about masturbation? Are sexually frustrated women seeing to their own needs through self-pleasuring? I don’t see any hard data, you should pardon the pun, on that topic.

We hear a lot about the horny dad and the tired mom, but what do you do if the “roles” are reversed – and dad is tired and mom is horny?

Curiously enough, I hear from way more men these days, who are exhausted, depressed or overweight and who have little or no libido, than I hear from women with the same problems. Sign of the times? You betcha!

But don’t sink to the lowest common denominator. Here’s one of my most popular tutorials, Sex Play — Tips and Techniques.

How can parents find common “ground” when it comes to when they might have sex (as in day of the week or time of day)? Does it always involve compromise? Can our internal clocks ever synch up?

Synching up schedules my not always be the solution. If we wait for that to happen, we could die waiting. The answer might be finding a middle ground. “I may not be up for full on fucking at the moment, but I’ll give you a fantastic hand-job.” Or “I can’t seem to get it up right now, but hand me your vibrator and I’ll send you to heaven!” I’m a huge proponent of mutual masturbation.

Another suggestion might be something like The MoodSign. We reviewed this very clever gismo awhile back. In fact, it was among our Best Products List for 2013. Check it out and see if something like this would help.

If parents are interested in kinking it up, what are some simple, not too scary ways to introduce it into the relationship?

Keep it safe and consensual. Always have a safeword. I developed a workshop called; The Gospel of Kink. I’ve also conveniently packaged this workshop into a workbook with the same title. You can find the book HERE!

GOK small cover

Both the workshop and book are designed to help people, like you, develop the skills they need to effectively communicate with one another and improve their problem solving skills. The workshop and book, as the title suggests, are specifically geared toward folks in kinky, BDSM, and alt-culture relationships, but even vanilla couples will find what I present very helpful.

Bondage games are always fun. And you don’t need anything beyond what you already have in your closets — silk scarves, belts, shoe strings, etc.

Nipple clamps, playing with sensations like ice cubes and hot wax, hair pulling, making use of blindfolds and gags

Discipline/Spanking is always fun too — a ruler, a hairbrush, a wooden spoon, a belt, rubber bands. See my tutorial: Spank Me, Daddy.

Role play is always a delight. Don’t forget about phone sex.

There are tons of instructional videos at Dr Dick’s How To Video Library.

I always suggest that couples read erotica aloud to each other. That never fails to get one’s motor purring.

I’d also love to talk with you about the taboo of sex, particularly with the parenting set, and how parents, moms, and dads, can work to break stereotypes without feeling like a sexual “deviant.”

Really? What would be so wrong about being a deviant?

Good luck

I Can’t Get No Satisfaction

Name: Trey
Gender: Male
Age: 24
Location: Charleston, SC
I’m a good looking guy. At least that’s what people tell me. I’m educated, have a good job, have a great sense of humor, and I’m also bi. I thought that being attracted to both women and men would increase the likelihood of me finding the sexual satisfaction I so desperately want and need.

I’m not afraid of commitment, but I can’t seem to get beyond casual hook ups and affairs that last only a few months. The sex is a hit or miss kind of thing, but even when the sex is great, I always seem to hit a wall. I can’t seem to get to the next level.

The New Year is upon us and I don’t want to remain stuck in this holding pattern. What am I missing? Any advice for someone like me?

Thanks for the timely question, Trey. And Happy New Year to you.

i'd totally fuck youYou bring up two very important skill sets — satisfying sex and relationship building. Despite the myths perpetuated by the popular culture, the two are not necessarily interdependent. Sexual satisfaction is one thing, and it can be achieved through traditional relationship models or not. Successful primary relationships can and often do depend on the sexual satisfaction of the partners, but not always. And given the diversity of intimate interests people have, it’s no wonder some come away from the experience frustrated and disappointed. Think of it as a combination lock. All the tumblers need to align for the lock to open.

The secret, it seems to me, is to discover precisely what it is you are looking for and deciding precisely what it is you are willing to expend getting what you want.

And I hope that your bisexuality has lead you to embrace more relationship models than what is traditionally handed us as the be all and end all—heterosexual monogamy. There is so much more out there.foreplay

That being said, I do have some generic thoughts about sexual satisfaction that are applicable to whatever relationship model you choose. Great sex is dependent on mutuality, even in a casual hook up. Be sure your partner knows he or she is loved, appreciated, or in terms of the casual hook up, respected.

If the connection you have with another has legs, so to speak, you will soon discover that either you or your partner has a stronger libido than does the other. That’s pretty common. Deal with this immediately, like adults. Don’t wait for your relationship to go broken. It’s just too easy to walk away from something that is floundering instead of investing the effort it would take to right it. Does that sound familiar? I wouldn’t be surprised if it does. Accommodations and compromise are always necessary in seeking the common good. And by that I don’t mean sinking to the lowest common denominator.  People come to compromise and accommodation through effective communication. If you don’t know how to do that, your relationship, of whatever stripe, is doomed.

female body as art 2Passion is not a dirty word, nor is sexual expression a sin. If you or a partner has religious scruples about enjoying you own body or that of your partner you’re headed for trouble. And remember, boredom in the bedroom is a recipe for disaster.

You should be well versed in self-pleasuring. In fact, the more you know about your body and the mysteries of your sexual response cycle the smoother things will go in partnered sex. Nowadays there is absolutely no need for anyone to come to partnered sex uninformed about sex in general and his or her sexuality in particular.

Like I said, mutuality is the key. And since we all evolve sexually, partners need to grow right along with each other. Make your sex play an adventure. Never hesitate to check in with one another to see how the pleasure thing is going. What’s worked last time is not necessarily gonna work next time.

Spontaneity is always a real good thing. Both partners need to take responsibility for seeing that their intimacy needs are being met. Sometimes that will involve fucking like bunnies, other times it will mean vegging-out in front of the boob-tube with a fist full of Häagen-Dazs.

Again, communication is key! Openness and honesty about one’s most secret sexual fantasies and desires is essential. Can’t trust your partner with your secrets? That’s never a good sign. Take responsibility for your own sexuality. Ask for what you need, but don’t neglect caring for yourself.

Seek your partner’s pleasure before your own. This is particularly important for a man.

If you are too busy to celebrate your sexuality with your partner, you are indeed too fuckin’ busy. Prioritize your life with your partner at its center.

nipple rubThere’s a fundamental difference between making love and fucking. Both have their place in a healthy sex life. And there ought also be room for solitary sex too. Everyone in entitled to privacy and private time, especially in a relationship.  If your job, or career, or whatever else interests you is more important than your relationship don’t expect that relationship to last.

Be creative in your sexual expression; toys, fantasies, role-playing, they’re all good. Don’t be afraid to experiment. Attend to making your sex play spaces fit the mood — romantic to down and dirty. One size does not fit all, if you catch my drift.

Stay in shape (and there’s not just one shape), get plenty of exercise, and keep yourself interesting and attractive to your partner. Pay attention to your personal hygiene. No one wants to bump someone with a smelly body or bad breath.

Make sure your partner is fully aroused before full-on fucking. And remember sex is way more than the old in an out. Finally, have a sense of humor about the whole damn thing; it will help take the edge off.

Good luck

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