Search Results: Older

You are browsing the search results for older

The extraordinary case of the Guevedoces

Catherine and his cousin Carla, Guevedoces in the Dominican Republic

Catherine and his cousin Carla, Guevedoces in the Dominican Republic

The discovery of a small community in the Dominican Republic, where some males are born looking like girls and only grow penises at puberty, has led to the development of a blockbuster drug that has helped millions of people, writes Michael Mosley.

Johnny lives in a small town in the Dominican Republic where he, and others like him, are known as “Guevedoces”, which effectively translates as “penis at twelve”.

We came across Johnny when we were filming for a new BBC Two series Countdown to Life, which looks at how we develop in the womb and how those changes, normal and abnormal, impact us later in life.

Like the other Guevedoces, Johnny was brought up as a girl because he had no visible testes or penis and what appeared to be a vagina. It is only when he approached puberty that his penis grew and testicles descended.

Johnny, once known as Felicita, remembers going to school in a little red dress, though he says he was never happy doing girl things.

“I never liked to dress as a girl and when they bought me toys for girls I never bothered playing with them – when I saw a group of boys I would stop to play ball with them.”

When he became obviously male he was taunted at school, and responded with his fists.

“They used to say I was a devil, nasty things, bad words and I had no choice but to fight them because they were crossing the line.”

We also filmed with Carla, who at the seven is on the brink of changing into Carlos. His mother has seen the change coming for quite a while.

“When she turned five I noticed that whenever she saw one of her male friends she wanted to fight with him. Her muscles and chest began growing. You could see she was going to be a boy. I love her however she is. Girl or boy, it makes no difference.”

Child on swing



So why does it happen? Well, one of the first people to study this unusual condition was Dr Julianne Imperato-McGinley, from Cornell Medical College in New York. In the 1970s she made her way to this remote part of the Dominican Republic, drawn by extraordinary reports of girls turning into boys.

When she got there she found the rumours were true. She did lots of studies on the Guevedoces (including what must have been rather painful biopsies of their testicles) before finally unravelling the mystery of what was going on.

When you are conceived you normally have a pair of X chromosomes if you are to become a girl and a set of XY chromosomes if you are destined to be male.

For the first weeks of life in womb you are neither, though in both sexes nipples start to grow.

Then, around eight weeks after conception, the sex hormones kick in. If you’re genetically male the Y chromosome instructs your gonads to become testicles and sends testosterone to a structure called the tubercle, where it is converted into a more potent hormone called dihydro-testosterone This in turn transforms the tubercle into a penis. If you’re female and you don’t make dihydro-testosterone then your tubercle becomes a clitoris.

Foetus at 12 weeks

When Imperato-McGinley investigated the Guevedoces she discovered the reason they don’t have male genitalia when they are born is because they are deficient in an enzyme called 5-alpha-reductase, which normally converts testosterone into dihydro-testosterone.

This deficiency seems to be a genetic condition, quite common in this part of the Dominican Republic, but vanishingly rare elsewhere. So the boys, despite having an XY chromosome, appear female when they are born. At puberty, like other boys, they get a second surge of testosterone. This time the body does respond and they sprout muscles, testes and a penis.

Imperato-McGinley’s thorough medical investigations showed that in most cases their new, male equipment seems to work fine and that most Guevedoces live out their lives as men, though some go through an operation and remain female.

Another thing that Imperato-McGinley discovered, which would have profound implications for many men around the world, was that the Guevedoces tend to have small prostates.

This observation, made in 1974, was picked up by Roy Vagelos, head of research at the multinational pharmaceutical giant, Merck. He thought this was extremely interesting and set in progress research which led to the development of what has become a best-selling drug, finasteride, which blocks the action of 5-alpha-reductase, mimicking the lack of dihydro-testosterone seen in the Guevedoces.

My wife, who is a GP, routinely prescribes finasteride as it is an effective way to treat benign enlargement of the prostate, a real curse for many men as they get older. Finasteride is also used to treat male pattern baldness.

A final interesting observation that Imperato-McGinley made was that these boys, despite being brought up as girls, almost all showed strong heterosexual preferences. She concluded in her seminal paper that hormones in the womb matter more than rearing when it comes to your sexual orientation.

This is still a controversial topic and one I explore later in the film when I meet Mati, who decided from the earliest age that though “he” looked like a boy, Mati was really a girl.

As for Johnny, since he developed male genitalia he has had a number of short term girlfriends, but he is still looking for love. “I’d like to get married and have children, a partner who will stand by me through good and bad,” he sighs wistfully.

Complete Article HERE!

Some of the Most Incredible Facts About the Human Body


That’s right; most of you isn’t even really you. In fact, between 2 and 6 pounds of your weight is actually just bacteria. Feel free to factor that in next time you’re on a diet.

Scientists have discovered that there are small deposits of magnetite in human brains. While they’re not 100% sure why, a leading theory is that the magnetic crystals aid our sense of direction by drawing upon Earth’s natural magnetic fields. Similar deposits can be found in the brains of homing pigeons, dolphins and bats, who all use magnetic fields to navigate.

The muscle that moves your jaw up and down (called the masseter) exerts more pressure than any other muscle in your body — up to 200 psi on your molars! However, we still wouldn’t recommend trying to chomp through a jawbreaker.

You might not be able to run faster, but you can run farther! Human bodies are perfectly engineered for running long distances, and it’s believed we evolved this way in order to hunt more efficiently. In fact, this type of hunting — called Persistence Hunting — is still practiced by hunter-gatherers in Southern Africa. You can see a video of the process here.

There are a few other primates who can toss objects, but humans are the only animals who excel at accurate, high-momentum throwing. Some scientists argue that our ability to throw is very much responsible for our success as a species, as it gave us a way to kill strong animals from a distance. Today it comes in handy as a way to play fetch with your dog.

That’s right, GOLD! However, it’s only 0.2 milligrams of gold, which by today’s standards will net you…less than a cent. But still. It’s real gold. In fact, there are a lot of valuable chemical elements floating around your body, including Rubidium, Boron and Scandium (all valued at thousands of dollars per kilogram). All together, the chemical elements of an average human body are worth about $160.

Of course you know that your fingerprints are unique but, as it turns out, the shape of your ears is, too! Biometrics developers are working on ways of implementing this knowledge in order to easily identify individual people in crowds from CCTV footage or to take attendance in a classroom. If you’re looking for a way to evade this new technology, we recommend wearing a hat, or maybe investing in some Spock ears.

Both the shape and the pattern of bumps on your tongue are entirely unique to each individual. In fact, both your teeth and the bacteria in your mouth are also unique between people — even identical twins! So the next time someone calls you unoriginal, just stick your tongue out at them and show ’em how special you are!

A baby has over 300 bones at birth, but adults have only 206. So what gives? Did you just lose some bones and not realize it? Nope! Actually, many of the bones in a baby’s body fuse together to create bigger, mega-bones (not a medical term), and that’s how you end up with only 206 in adulthood.

Babies are born exhibiting a number of fascinating reflexes, including the ability to walk on a flat surface (as long as the baby’s body and head are supported). Another baby superpower is called the Palmar Grasp, which allows the baby to grab onto an object with surprising strength. In fact, some babies can even support their own weight (although we don’t advise trying to recreate the picture above).

And speaking of superpowers, here’s a shout out to your liver, which is basically the superhero organ of the human body. Your liver performs over 500 functions, including producing bile and cholesterol, removing bacteria from the bloodstream and — of course — clearing the blood of toxins from drugs and alcohol. Keep that in mind next time you complain about working overtime.


And if that’s not impressive enough for you, it’s recently been discovered that your nose can smell at least 1 trillion scents, making it the most sensitive organ in the body by a large margin. However, I think we can all agree that there are some scents you might be better off forgetting.

It’s called the Mammalian Diving Reflex, and it is seriously one of the coolest things your body is capable of. When you splash cold water on your face, your body thinks it’s going for a swim, and prepares accordingly. First, your heart rate slows down 10-25%. Then the blood vessels in your extremities constrict and send more blood to your lungs. As a result, you use up less oxygen and — if you were swimming — would be able to stay underwater longer.

Maybe the Mammalian Diving Reflex is what the people in face wash commercials are actually demonstrating…

Ounce for ounce, human bones can withstand a lot more pressure than steel. In fact, a cubic inch of human bone could bear a load of 19,000 pounds! Bones are also a lot lighter, less dense and more flexible than steel, which makes them a great material for, you know, supporting your entire body. Steel wins when it comes to building materials, though, because using bones would be a little too spooky.

Like, a lot of saliva. In fact, throughout the course of your lifetime, the amount of saliva you produce could fill the Olympic-size swimming pool pictured above…twice. Maybe even more if you spend a lot of time thinking about Warhead candies.

A single strand of hair can support about 100g (which is equal to about two candy bars). But twisted together, one person’s entire head of hair (consisting of about 150,000 individual strands) could support 12 tons of weight — that’s the weight of 2 elephants!

Not only is hair very strong, it’s also virtually indestructible. Aside from being flammable, hair won’t break due to extreme temperatures, and it’s also resistant to a lot of acids and other corrosive chemicals.

Although hair doesn’t easily break, you still lose between 60 and 100 strands of it every day. Think of how many elephants you could be lifting if you didn’t!

This reflex, known as the Photic Sneeze Reflex, is present in 18-35% of the population, and it causes people to sneeze when exposed to a change in light intensity (such as leaving a dimly lit building on a sunny day). Sneezing can also occur in some people after eating spicy foods, or even when they’re full after eating. This phenomenon is not completely understood, but we’re pretty sure it’s the lamest superpower ever.

While your eyes remain the same size throughout your entire life, your ears and nose will continue growing as you get older. This is partially due to the fact that they are made out of cartilage (rather than bone), but is mostly as a result of gravity. So they’re not actually growing as much as sagging. Regardless, you’ll be able to tell your grandkids “all the better to hear you with,” so that’s pretty cool.

Since fat is essentially an endocrine organ, it needs a supply of blood to function. So, as fat is added to your body, your body in turn constructs blood vessels and capillaries to provide blood to the fat cells. For each pound of fat, your body creates 7 miles of blood vessels, and that means your heart has to work harder to pump blood throughout your body. This is part of the reason why obesity is often linked to heart disease, and is also part of the reason why we’re having a salad for lunch.

Complete Article HERE!

20 Interesting Facts You Never Knew

Everyone took a sexual education course in middle or high school to learn about the “birds and the bees.” However, there are a lot of facts that sex ed teachers leave out. These facts are sometimes the most interesting and the most useful in real-life situations. Here are 20 little known facts about “doing it.”

Patterns In Sexual Desire

Most women have an increase in sexual desire around the time that they ovulate each month. This is nature’s way of making sure the Earth stays well-populated.

It Sounds Gross But…

Semen can be great for the facial pores and can even help with acne. The male-produced “facial cream” can also prevent wrinkles.


A Headache Is A Bad Excuse

We’ve all heard the cliche “my head hurts” excuse for turning down sex. However, sex often helps with pain, especially with headaches.

We’re Not Judging

Many straight men enjoy having their anal areas stimulated, and that is totally okay! Sexual experts say that the anal areas are packed full of nerves and can make a male orgasm so much better.

1, 2, 3…And They Keep Coming!

Women can orgasm an unlimited amount of times. Men generally need a period of time after orgasming to recover. However, women need barely any time and are ready to go as many times as they please.

Men Are Erect…A Lot

It is said that many men experience about 11 erections every single day. While they may not be raging every single time, it does happen pretty often.

Celery Can Arouse

Yes, celery. The pheromones in celery can cause arousal in men. In addition to the arousal, the vegetable also makes men who eat it more attractive to women.

The Left Side Is The Best Side

A group of scientists found the upper left quadrant of the clitoral head is the most pleasurable spot to touch. So, it’s okay to tell him to go “a little to the left.” It’ll be sure to make the sex even more enjoyable.

Orgasms Are Different

A man’s orgasm lasts about 22 seconds while a woman’s lasts about 18. It is also very common for it to be uncomfortable to pee after having sex because of an antidiuretic hormone that prevents urine from freely flowing.

Sex Can IMPROVE With Age

Sexual attraction is a life-long drive. The reason most older people don’t have sex very often is that there is a lack of opportunity to have sexual encounters.

Get Your Heart Going

Sex is a great way of getting in your daily cardio exercise. During an orgasm, heart rates can reach between 140 and 180 bpm.


Lube Can Make A Difference

While lube is considered a sex tool for older people, many sexual experts say that a little lubricate can make the difference between pain and pleasure during sex. This doesn’t mean the woman is not turned on. Natural “lube” can come and go without any warning.

Penetration Is NOT The Secret

Most women do not orgasm from penetration alone. The majority of women need some type of clitoral stimulation to reach their climax. It has nothing to do with size or penetration.

Everything Expands

The penis is not the only thing that grows during a sexual encounter. In fact, the testes grow by 50% and the vagina can double in size when aroused.

More Sex Makes You More Appealing

After having sex, a woman’s estrogen levels double. When estrogen levels are higher, a woman’s hair can look shinier and her skin can even feel softer.

Not Only People Can Be Arousing

Some people have sexual attraction to objects instead of specific people. There is a woman known to be sexually aroused by the Eiffel Tower.

Have Sex, Live Longer

Scientists have found that orgasms can actually prolong your life. That’s right, the more sex you have, the longer you can live.

Humans & Dolphins Alike

As far as sex is considered, dolphins and humans have one key fact in common. The two mammals are the only animals in the world that have sex for pleasure.

Sex Everyday Keeps The Doctor Away

Sex can actually help you stay healthy. Many doctors believe this is because sex can lower blood pressure and greatly decrease stress levels.

It’s Like Two Puzzle Pieces

Not every penis, or vagina, is the same. If a guy is too large, women can control penetration by changing positions. If he is too small, there are many toys, etc that couples can invest in.


Chlamydia at 50… Could it be you?

by Jenny Pogson

senior intimacy

If you think only young people are at risk of sexually transmitted infections, think again – rates could be on the rise in older adults.

With more of us living longer and healthier lives, and divorce a reality of life, many of us are finding new sexual partners later in life.

While an active sex life comes with a myriad of health benefits, experts are warning those of us in mid-life and beyond not to forget the risk of contracting a sexually transmitted infection from a new partner.

Figures suggest rates of infections have been on the increase among older people in the US and UK in recent years and there is a suggestion the same could be happening in Australia.

Chlamydia, a common bacterial STI, is on the up among all age groups in Australia, and has more than doubled in those over 50 since 2005; going from 620 cases to 1446 in 2010.

Gonorrhoea, another bacterial infection, has seen a slight increase in the over 50s, rising from 383 infections in 2005 to 562 in 2010.

While these increases could partly be attributable to more people being tested, the trend has caused concern in some parts of the medical community here and overseas.

Cultural shift

Older people are increasingly likely to be single or experiencing relationship changes these days, according to the UK’s Family Planning Association, which last year ran its first sexual health campaign aimed at over 50s.

It’s much easier to meet new partners, with the advent of internet dating and the ease of international travel. Plus, thanks to advances in healthcare, symptoms of the menopause and erectile dysfunction no longer spell the end of an active sex life.

But despite this, education campaigns about safe sex are generally aimed at younger people; not a great help when it’s often suggested that older people are more likely to feel embarrassed about seeking information about STIs and may lack the knowledge to protect themselves.

And, as noted by Julie Bentley, CEO of the UK’s Family Planning Association, “STIs don’t care about greying hair and a few wrinkles”.

Risky sexual practices

Dr Deborah Bateson, medical director at Family Planning NSW, started researching older women’s views and experience of safe sex after noticing a rise in the number of older women asking for STI tests and being diagnosed with STIs, particularly chlamydia.

The organisation surveyed a sample of women who used internet dating sites and found, compared with younger women, those aged between 40 and 70 were more likely to say they would agree to sex without a condom with a new partner.

Similarly, a telephone survey commissioned by Andrology Australia found that around 40 per cent of men over 40 who have casual sex do not use condoms.

While the reasons behind this willingness to engage in unsafe sex are uncertain, Bateson says older people may have missed out on the safe sex message, which really started to be heavily promoted in the 1980s with the advent of HIV/AIDS.

In addition, older women may no longer be concerned about becoming pregnant and have less of an incentive to use a condom compared with younger women.

“There is a lot of the information around chlamydia that relates to infertility in the future, so again for older women there may be a sense that it’s not relevant for them,” she says.

However, the Family Planning survey did find that older women were just as comfortable as younger women with buying condoms and carry them around.

“There’s obviously something happening when it comes to negotiating their use. Most people know about condoms but it’s just having the skills around being able to raise the subject and being able to negotiate their use at the actual time,” Bateson says.

As with most things in life, prevention is better than cure – something to remember when broaching the topic of safe sex and STIs with a new partner.

“If you’re meeting a new partner, they are probably thinking the same thing as you [about safe sex],” says Bateson.

“So being able to break the ice [about safe sex] can often be a relief for both people.”

Stay safe

Anyone who has had unprotected sex, particularly with several people, is potentially at risk of STIs, says Professor Adrian Mindel, director of the Sexually Transmitted Infections Research Centre based at Westmead Hospital, Sydney.

“People who are changing partners or having new partners, they and their partner should think about being tested,” he says.

“Also think about condom use at least until [you] know [the] relationship is longer lasting and that neither of [you] are going having sex with anyone outside the relationship.”

The UK’s Family Planning Association also stresses that STIs can be passed on through oral sex and when using sex toys – not just through intercourse.

It also notes that the signs and symptoms of some STIs can be mistaken as a normal part of aging, such as vaginal soreness or irregular bleeding.

And remember that often infections don’t result in symptoms, so you may not be aware you have an STI. However, you can still pass an infection on to a sexual partner.

So if you are starting a new sexual relationship or changing partners, here is some expert advice to consider:

  • If you have had unprotected sex, visit your GP to get tested for STIs. This may involve giving a urine sample to test for chlamydia, examination of the genital area for signs of genital warts, or a swab of your genitals to test for STIs such as herpes or gonorrhoea. A blood test may also be required to test for syphilis, HIV and hepatitis B.
  • If you are starting a new relationship, suggest your partner also gets tested.
  • Use a condom with a new partner until you both have been tested for STIs and are certain neither of you is having unprotected sex outside the relationship.
  • If you have symptoms you are concerned about, such as a urethral discharge in men or vaginal discharge, sores or lumps on the genitals, pain when passing urine or abdominal pains in women, see your GP.

Complete Article HERE!

When did sex become shameful?

By Hanna G Ruby

Once upon a time sex was enjoyed without shame, as a gift of God, Goddess, the Great Spirit – an act of joy, of devotion, something perfectly natural and wholly divine – all at the same time.  Once upon a time the goddesses were venerated as the embodiment of love, passion, and sex, which were considered holy when performed in reverence for and in service of the female divinity.

But the mindset of patriarchy killed off the Goddess more than five thousand years ago. She was constrained to submission at worst, or virginal purity and celibacy at best; her divinity denied. With that, the idea of sexuality as spirituality, as something inherently divine, was eradicated for all women – young and old. Indeed, for all men as well!  Sexuality was severed from spirituality and became its extreme opposite; sex was dirty, primitive, and instinctual (and feminine in nature), while spirituality was pure and clean and transcendent (and masculine in nature).

In the West, however, it was only from our Bible onward that sexuality became a sin, the means by which the devil could tempt mankind into damnation, a shameful necessity of physical gratification that was obscene and dirty. Only from our Bible onward, were women considered inherently sinful and destined for eternal punishment.

Even before Eve bit that apple, there was poor, feisty Lilith (born initially as one with Adam – “male and female created He them” says the first Biblical reference), who, according to legend, preferred to have sex on top. Lilith represents lunar consciousness (waxing and waning, death and rebirth), sexuality, body, and intuitive wisdom – all of which patriarchy degraded and denied. She got a terribly bad press.

Previously, the Goddess had ruled the mysteries of sexuality, birth, life, and death. Now the patriarchal God took control of life and death, and split procreation and motherhood from sexuality and “magic and mystery”. Lilith refused to submit and flew off in a rage. Until recent decades, she has been universally demonized as seductive, witch, outcast – the enraged, avenging goddess, wife of Satan.

Solar was split from lunar; psyche from soma or physical, corresponding to a general disassociation from the body. Mind and body, spirit and body, soul and body were split entities, and unequal. The body was inferior, an unfortunate necessity – together with its most basic of functions, sex; and it was associated with the feminine. (I once read an old text that described women as “bags of filth”. The males’ organs of excretion were not referred to.)

Male and female were unequal; spirit and nature were unequal. Man headed the chain of command – after God. As women, and as a culture, we have paid dearly for this division. The misogyny of the patriarchy affected all cultures in the last 2000 years, one way or another.

The fierce, sexual, independent-spirited wise dark goddess aspect of Lilith was replaced by submissive Eve, who was yet blamed for the whole messy business anyway. She was the sinful one, secondary to Adam, and cursed forever to give birth in pain. (Medieval midwives were sinning when they alleviated the pain of childbirth.)

As long as Eve is sinful and physical matter corrupt in any way whatsoever, our sexuality is compromised – and our liberation incomplete. This split must be healed.

I am proposing that sexuality and spirituality are aspects of the same thing; that the split between psyche and soma (the physical) is resolved in the energetic unity of a higher order. “We have lost contact with what unites them,” says Alexander Lowen in The Spirituality of the Body.  Sexuality is psychosomatic – and by that I mean, not that it’s some kind of illness, in the more common meaning of the word, but that it overtly operates on both the physical and the psychic level.

Where science and religion are finding rapprochement in the infinite wave world of quantum physics, we find fresh metaphors for the lost unifying element. Waves of sexual sensations that emanate from the body can be visualized as cosmic, psychic energy, high-frequency vibrations that bridge us to higher consciousness.

These metaphors indicate possibilities that have profound implications generally, and more so for aging women today.

Complete Article HERE!

SEO Powered by Platinum SEO from Techblissonline