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The extraordinary case of the Guevedoces

Catherine and his cousin Carla, Guevedoces in the Dominican Republic

Catherine and his cousin Carla, Guevedoces in the Dominican Republic

The discovery of a small community in the Dominican Republic, where some males are born looking like girls and only grow penises at puberty, has led to the development of a blockbuster drug that has helped millions of people, writes Michael Mosley.

Johnny lives in a small town in the Dominican Republic where he, and others like him, are known as “Guevedoces”, which effectively translates as “penis at twelve”.

We came across Johnny when we were filming for a new BBC Two series Countdown to Life, which looks at how we develop in the womb and how those changes, normal and abnormal, impact us later in life.

Like the other Guevedoces, Johnny was brought up as a girl because he had no visible testes or penis and what appeared to be a vagina. It is only when he approached puberty that his penis grew and testicles descended.

Johnny, once known as Felicita, remembers going to school in a little red dress, though he says he was never happy doing girl things.

“I never liked to dress as a girl and when they bought me toys for girls I never bothered playing with them – when I saw a group of boys I would stop to play ball with them.”

When he became obviously male he was taunted at school, and responded with his fists.

“They used to say I was a devil, nasty things, bad words and I had no choice but to fight them because they were crossing the line.”

We also filmed with Carla, who at the seven is on the brink of changing into Carlos. His mother has seen the change coming for quite a while.

“When she turned five I noticed that whenever she saw one of her male friends she wanted to fight with him. Her muscles and chest began growing. You could see she was going to be a boy. I love her however she is. Girl or boy, it makes no difference.”

Child on swing



So why does it happen? Well, one of the first people to study this unusual condition was Dr Julianne Imperato-McGinley, from Cornell Medical College in New York. In the 1970s she made her way to this remote part of the Dominican Republic, drawn by extraordinary reports of girls turning into boys.

When she got there she found the rumours were true. She did lots of studies on the Guevedoces (including what must have been rather painful biopsies of their testicles) before finally unravelling the mystery of what was going on.

When you are conceived you normally have a pair of X chromosomes if you are to become a girl and a set of XY chromosomes if you are destined to be male.

For the first weeks of life in womb you are neither, though in both sexes nipples start to grow.

Then, around eight weeks after conception, the sex hormones kick in. If you’re genetically male the Y chromosome instructs your gonads to become testicles and sends testosterone to a structure called the tubercle, where it is converted into a more potent hormone called dihydro-testosterone This in turn transforms the tubercle into a penis. If you’re female and you don’t make dihydro-testosterone then your tubercle becomes a clitoris.

Foetus at 12 weeks

When Imperato-McGinley investigated the Guevedoces she discovered the reason they don’t have male genitalia when they are born is because they are deficient in an enzyme called 5-alpha-reductase, which normally converts testosterone into dihydro-testosterone.

This deficiency seems to be a genetic condition, quite common in this part of the Dominican Republic, but vanishingly rare elsewhere. So the boys, despite having an XY chromosome, appear female when they are born. At puberty, like other boys, they get a second surge of testosterone. This time the body does respond and they sprout muscles, testes and a penis.

Imperato-McGinley’s thorough medical investigations showed that in most cases their new, male equipment seems to work fine and that most Guevedoces live out their lives as men, though some go through an operation and remain female.

Another thing that Imperato-McGinley discovered, which would have profound implications for many men around the world, was that the Guevedoces tend to have small prostates.

This observation, made in 1974, was picked up by Roy Vagelos, head of research at the multinational pharmaceutical giant, Merck. He thought this was extremely interesting and set in progress research which led to the development of what has become a best-selling drug, finasteride, which blocks the action of 5-alpha-reductase, mimicking the lack of dihydro-testosterone seen in the Guevedoces.

My wife, who is a GP, routinely prescribes finasteride as it is an effective way to treat benign enlargement of the prostate, a real curse for many men as they get older. Finasteride is also used to treat male pattern baldness.

A final interesting observation that Imperato-McGinley made was that these boys, despite being brought up as girls, almost all showed strong heterosexual preferences. She concluded in her seminal paper that hormones in the womb matter more than rearing when it comes to your sexual orientation.

This is still a controversial topic and one I explore later in the film when I meet Mati, who decided from the earliest age that though “he” looked like a boy, Mati was really a girl.

As for Johnny, since he developed male genitalia he has had a number of short term girlfriends, but he is still looking for love. “I’d like to get married and have children, a partner who will stand by me through good and bad,” he sighs wistfully.

Complete Article HERE!

Beginning Sex Play — Tips and Techniques

I most frequent hear from your average Dick and Jane, (or Dick and Dick, or Jane and Jane) who want to spice up their sex life. When they write to me they inevitably describe the kind of sex they’re currently having. And almost universally that description makes this grown man cry. Jeez, the boredom. How can they stand it? It’s a wonder any of them are having sex at all.

big funWhat’s with all the humdrum, run of the mill, we’ve always done it that way mentality? Are ya’ll afraid that if you add a little something new to your sex chore from time to time that the sky will fall? Holy cow!

Today’s tutorial is yet another attempt to motivate you to get off your butts and make something interesting happen in the sex department. We’ll begin today with what was once called foreplay.

First off, I hate the word “foreplay” because it suggests that all the really great sex play activities out there are only a lead up to a single — more important activity — that is fucking. It also implies that ya’ll can dispense with the one in order to hurry up and get to the other. And that, sex fans, is always a huge mistake.

From now on I want you to banish “foreplay” from your vocabulary. Instead let’s start using “Beginning Sex Play.” It says it all. It says it’s at the beginning, but there’s no suggestion that anything in particular must follow.amazing sex secrets

I’m of the mind that we’d all be better served if we thought of sex play as a continuum of pleasure with a beginning, middle and an end. If you ask me, our sex play ought mirror our sexual response cycles — arousal, plateau, orgasm and resolution. That way we’re less likely to overburden one particular activity at the expense of all the others. Get it? Got it? Good!

Experienced sex fans agree; the best sexual encounters include an extended period of sensual play at the beginning of most all sex play. This brings increased pleasure to both partners, and will make whatever else that might follow more satisfying. Just remember, beginning sex play can be a meal in itself.

Beginning sex play brings spice to the encounter because it gets our motors started. Even all you major sex athletes out there, who are perpetually primed for sex, will benefit from more beginning sex play. It will help cool your jets and make the encounter last longer than a firecracker. And I know that you know what I mean!

erotic talkIn our hectic rush-around-world, beginning sex play is particularly important. It helps us transition from the daily cares and woes to the realm of sensual pleasures. The workaholics among us need more time to become fully aroused. Our minds are still filled with the junk of the day, and not yet ready to give or receive pleasure. And pleasuring and being pleasured, I might add, takes a big attitude shift from that of the rest of the day. In fact, if you’re gonna try and approach sex and pleasure with the same mindset as you have on the job or with the kids, give it up now and be done with it. You’ll only walk away from the encounter disappointed.

Beginning sex play primes us for maximum pleasure. Us men folk will have the time we need to come to full erection and the women folk will have the time they need to properly lubricate. (By the way, this is called the arousal stage in our sexual response cycle).

When we stop thinking of beginning sex play as “foreplay” we realize there is no such thing as spending too much time giving and getting pleasure. If beginning sex play evolves into full-on fucking — SWELL. Both partners will be fully aroused and fucking will flow naturally and effortlessly from the pleasure enjoyed at the beginning of sex play.

Beginning sex play can include everything from chocolate and whipped cream to whips and chains. But let’s not get too far ahead of our selves. Let’s start at the beginning of beginning sex play, shall we? beginner's guide

Most people miss out on the pleasure of undressing with and for their partners. Stripping out of, or being helped out of our daily wear and into something sexy or nothing at all can be very arousing. It’s also a visual signal that we’re shifting out of our work-a-day world and entering the realm of sensuality. Stripping is an art form, ya know. We could all learn a lesson or two from the folks who do this for a living, but more about this in THIS tutorial.

Creating the right sex environment is important too. Make sure the room is warm. Proper lighting and music will surely add to the mood. Scents are also important. More and more people are incorporating erotica into their sex play — reading a sexy story together or enjoying some hot porn will make the encounter memorable.

Most women complain that their partners don’t kiss long enough and rush the kissing to get at their pussy. Guys, what the fuck? You want pussy? Use your mouth to maximum advantage kiss and nibble all over everything. Literally devour your partner with your mouth. Believe me, if you do this right, by the time you get to her pussy she’s gonna want to give it up big time.

Hanky Spanky Gift SetBeginning sex play is the perfect time for setting the mood for all that might follow. It’s a time for sharing fantasies, role-playing, dirty talk or some full body massage. Always have some nice lotion available then use your hands, forearms, feet and elbows to knead your partner’s muscles and naughty bits.

Certain areas on the body are more hot-wired than others. It’s your job to find each and every one your partner has. As you massage vary your strokes and touch to stimulate your partner. Roll your fingertips across his or her nipples and behind his or her ears as you kiss him and tease her with your tongue.

If you’re doin things right, your partner will be moaning with pleasure. If she or he starts getting impatient it’s time to bring out the restraints. There’s nothing like some hot erotic bondage to punctuate the beginning sex play.

While your darling is subdued and possibly blindfolded, crank things up a notch. Add different sensations and stimuli, a warm chocolate sauce followed by ice cream. A fur mitt followed by a Loofah. Introduce some sex toys — a vibrator, tit clamps, or an anal simulator.

Don’t forget to check in with your partner from time to time. Ask for some feedback and direction. Do you like this? Or do you like this better? If you presume that you know what your partner likes simply because he or she liked it before, that, my friend, is a recipe for boredom and the dreaded bed death. If words fail you, SHOW your partner what you want. Then encourage your partner to do the same.002

Beginning sex play is not about pressing the right buttons in the right order. It is about understanding what makes your partner tick and supplying and applying those things to their greatest sensual advantage. There are many ways to give your partner extreme pleasure, and it all begins in your brain. Beginning sex play is as much of an art form as it is a necessity. Finally, the basic premise behind all of this is that the great lover is one that gives pleasure because it is its own reward, not a means to getting something else.

Good luck

New Mommy Woes

Name: Megan
Gender: Female
Age: 29
Location: Toronto
I’m a new mother and this is my first child. He was born 3 weeks ago, but I am still enthralled with the miracle of it all. So far motherhood has been pretty wonderful. Sure I’m tired, but just holding my son in my arms makes me so happy I sometime cry with the joy. There is a problem, however, my husband wants to resume our sex life, but I have absolutely no interest. I love him dearly and I know I owe him this, but I have no libido. What can I do?

Yep, this is common enough complaint. This is precisely the place where new parents experience the most strain on their relationship. And when you think about it, it’s not all that surprising. Most new mothers are exhausted by the expectations of motherhood. And first babies are the most challenging. Added to these burdens her partner eagerly awaits the resumption of the sort of sex life that was in place before the pregnancy. New mothers often feel like their husband is just one more person to service, one more person with needs and demands that are keeping her from much-needed sleep.

New Mother LoveNew mothers can find sex unappealing for reasons both physical and emotional. If you’re breastfeeding, your breasts are sore, heavy, and leaky. Your body just doesn’t feel sexy, with its stretch marks, cellulite, dark nipples and dark line down the abdomen, not to mention the weight gain and varicose veins. Then there is lochia, the discharge after the birth, which lasts for 3 to 4 weeks and does not smell very good. If you had an episiotomy, the stitches are very uncomfortable and you may worry about infection. Your hormones may still be in a state of flux, so you feel moody or depressed. And you may not have a good method of birth control, so sex is the last thing on your mind!

Some doctors recommend that new mothers refrain from sex until their first post partum examination, usually about 6 weeks after the birth.NewMother

So if you and your husband weren’t warned about all this, you’re probably both totally unprepared. And if you can’t talk about it, there will be trouble ahead. Many new fathers labor under the misconception that once the baby is born, their sex life will return to normal. Besides this being completely unrealistic; it mostly puts pressure on the wife to do, as you suggest, her ”duty”. This is no way to pursue a sex life together.

Of course, new fathers can help their partner move beyond those feelings of sexual disinterest by being an involved parent and helping around the house.

There are loads of sex things new mothers can do that will pleasure their partner that don’t involve full-on fucking. Hand jobs and blowjobs are always welcome. Reading erotica aloud to each other can be fun. Mutual masturbation, or even watching him and cheering him on as he squeezes one out is also an option. But probably the thing that will get your libido back is a lot of touching, massaging, hugging, kissing, and snuggling and not as a prelude to sex, but just for the joy of it. These things, without the pressure to perform will help reestablish the pair-bond between you and your old man, which will inevitably lead to the long awaited fuckfest.

Good luck

Hey, Where’s My Big “O”?

Name: BJ
Gender: Female
Age: 23
Location: PA
I’ve been sexually active for several years now and have yet to reach an orgasm. Oral sex, intercourse nor masturbation have been effective. Is there something wrong with me, what might help?

I’d be very much surprised if there was actually something physically wrong with you. But you clearly have some difficulty letting go. And simply put, an orgasm is letting go of built up sexual tension.the big O

Lot of preorgasmic women don’t feel entitled to an orgasm, for one reason or another. Other women are simply unversed on how to make the big “O” happen in their own fine self. Sometimes it’s a combination of both resistance and a lack of know how.

I once had a client, a woman in her late 30’s, the mother of three and a devote Catholic. She was preorgasmic too. Her big stumbling block was fear. You got it; fear of having an orgasm. She had heard from other women over the years how powerful orgasms were and how much fun they were. My client somehow got it in her head that if she were to ever let go and give up that long-awaited screamin’ meme, her entire world would collapse. She’d become a sex addict, neglect her children, divorce her husband and turn her back on God…the whole enchilada.

With that kind of mindset, this little lady wasn’t gonna let herself cum no how.

the big O 2I had to reassure her that, as delightful as orgasms are, they are not like crack cocaine. I told her there was no chance that she’d fly to pieces as a mother, wife and friend of Jesus if she were to diddle herself once in a while. I had to keep repeating this over and over till it finally sank in. You talk about hardheaded! In the end, she had her precious orgasm, joined the ranks for the sexually satisfied and lived happily ever after. …Well, I can’t honestly say about the happily ever after part, but she sure did smile a whole lot more afterwards.

Back to you BJ, I don’t suppose there’s any way you could have one of your gal-pals show you how it’s done, is there? The reason I ask is most guys learn how to choke the chicken by watching, or being instructed by another guy. Us men folk are really good about doin that for one another. Women, on the other hand, don’t seem to do this for one another as much. Which is a freakin’ pity, if ya ask me.

If you can’t (or won’t) get a pal to show you around proper pussy pleasuring, I have another suggestion for you. Mozie on over to DR DICK’S HOW TO VIDEO LIBRARY  and check out a swell instructional video. (There’s a link to this marvelous resource in the header.) Do a quick search for “female masturbation” and let the experts show you a thing or two. You’ll be so glad you did.

Another great resource: The Ultimate Guide to Orgasm for Women: How to Become Orgasmic for a Lifetime by the brilliant Mikaya Heart. By the way, you can find a dynamite two-part interview with Mikaya HERE and HERE!ultimate-guide-to-orgasm-for-women-lg

Here are a few tips:

Get in the mood

Relax as much as you can. Whatever that means for you. Take a warm bath or have a glass of wine. Ensure your privacy: turn off the phone, lock the door for privacy from roommates, kids, whoever. Find a comfy position. Most women start out lying on their backs, legs bent and spread apart, with feet on the ground. Remove most or all of your clothing (or as much as your comfortable with).

Explore your body

Run your hands along your body, lingering along areas that are more responsive to touch than others. If you’re able to do it, and you’ve never done it before, you might want to try to look at your genitals in a mirror. Because so many women are raised with negative messages about their bodies, and particularly their genitals, being able to see while you touch can be powerful and surprising. Find and touch your inner and outer labia, your clitoris, your vagina and your perineum.

Touch yourself

Using one or two fingers, rhythmically stroke the different parts of your vulva, paying particular attention to your clitoris and labia. Experiment with different types of pressure, speed and motion. Try placing a finger on either side of the clitoris and stroking up and down, or placing two fingers on the clitoral hood and rubbing in a circular motion.


Try different types of touch: stroke, tickle, knead, pinch, or lightly pull your genitals. Try using one or several fingers, the palm of your hand, even your knuckles.

Build up excitement

Learn to hold onto sexual excitement by building up and then reducing or temporarily stopping the stimulation. (Men do this all the time when they jack-off.  It’s called edging.) Pay attention to how your body is responding. It will tell you the particular stroke that feels best and when to pick up or slow down the tempo.

Don’t forget to breathe

Many women hold their breath as they get excited. Be mindful of your breath and learn to play with breathing during arousal. Try to breathe deeply rather than hold your breath. This can help release the sexual energy, rather than fight it.

Moving a little

In addition to often holding our breath, many women tense up and don’t move much at all when wtheye masturbate. This might work for you just fine, but if you haven’t explored movement, it’s worth a try. Moving while you are getting turned on, and moving during orgasm can change the way you experience pleasure in your body. For some women this means rocking their pelvis. For others it means moving their legs or torso side to side. Find what movement works for you and then intentionally start doing it while you masturbate.

Letting go

If your hand gets tired, give yourself a rest, switch hands, or try a vibrator. If you’re on the brink of orgasm, but can’t quite get over the hump, try to become more conscious of your breathing, give yourself extra stimulation: caress your nipples, or try thrusting your other fingers or a dildo in and out of your vagina.

Ride the Wave

As you begin to orgasm, continue the stimulation through the orgasm. Lighten up on the stimulation during the first extremely sensitive moments but keep it going to enjoy those little pleasurable aftershocks. Your first orgasm may feel like a blip or a blast, but the more you practice, the more variety you will experience.


Sexual fantasy can be a double edged sword when it comes to masturbation. If you have trouble getting yourself in the mood or getting over the top, a hot fantasy may be just the ticket. I often suggest reading erotica to get in the mood. However, when we fantasize some of our attention is taken away from what’s happening in our bodies in the moment. Sometimes what is getting in the way of us enjoying masturbation is that distance from our bodies. It’s good to try everything, but be mindful of whether or not your fantasies are acting as an enhancer or a distraction.

hitachi-magic-wand-2Some final thoughts…
Vibrators take some of the manual labor out of masturbation by providing direct, intense physical stimulation to the clitoris.  check out all the marvelous vibrators we’ve reviewed for you at Dr Dick’s Sex Toy Reviews.

Many women learn to jill-off in the bath or shower. A direct the stream of water on your vulva and clitoris can be a game changer. Vary the pressure, the pulsation, and the temperature. Alternate methods: slide your butt over the drain so your legs are up in the air and your genitals are up under the tub faucet (rather awkward but do-able for some), or use Jacuzzi jets.

Rub against something–a pillow, the corner of some furniture, a washing machine in operation.

Dildos can be a pleasurable accompaniment to clitoral masturbation, as they offer the fullness of penetration and can also stimulate the g-spot.

Write back again, BJ, and let me know how things go. If you’re not successful, I still have a few other tricks up my sleeve.

Good luck

Boys Will Be Boyz

Name: TJ
Gender: Male
Age: 41
Location: ma
ever since i was a teen i have had the hots for my dad. i would walk into the bathroom on him, or his room to seesmoking him naked and to see his dick. i use to love catching him jack off. i loved to see him in his boxers, and would jack off in his boxers. i even would play with him when he was a sleep get him hard and jack myself off. i thought i was over this till he stayed with me over the weekend. he came out of the bathroom in just his boxers. i was only wearing my boxers also. i became hard and excited. the old thought of playing with his cock came back. that night i went into the guest room took out his penis from his boxers and played with it. till it was erect. i then took a pair of his boxers and jacked off in them. i am 41 now should i have out grown this attraction to my dad?? he knows i am gay, we have talked several times about my playing with him but should this attraction continue?? — lost and confused in dads boxers

This is precious, TJ. You’ve been fondlin’ and jerkin’ off your old man for decades, albeit while he “sleeps.” (He’s one hell of a deep sleeper, huh?) He knows all about you, your attraction to him and your late night play sessions with his cock and underwear. But he still comes for a visit. And predictably, you set upon him again in his sleep. How may more incredible things could you possibly add to a single paragraph?

And all you want to know is, is it odd that you continue to behave like this with your father and continue to have this attraction to him now that you’re 41 years old. AMAZING! Odd? Yeah, I’ll say it’s odd!

Where to begin? Oh skip it! If you and your dad (now somewhere in his late 60’s or even 70’s) are still playing at this little game it must be pretty harmless by this time.

Your behavior and attraction continue because you feed it, darling. No big mystery there.

Name: Alan
Gender: Male
Age: 41
Location: Victoria
I find it takes me for ever to jack off even watching videos it can take 40 minutes an when I do shoot it is only a small amount.

nipplesYou don’t say, Alan! I’ve never heard that question before. No wait, that’s baloney. I’ve heard and written extensively about this very issue.

Look to your right. See the CATEGORY pull down menu in the sidebar? EXCELLENT! Now search for the terms: “Ejaculate” and “Ejaculation Concerns” and “Cum.”  Between these categories you will find the answers you are looking for.

Here’s a tip: you’ll also want to check out what I’ve had to say about “Kegels.” You’re gonna want to know all about these handy-dandy exercises to tone up your PC muscle. Both men and women need to attend to their PC muscle. Not sure what the fuck I’m talking about. Not to worry. You have some fun reading and listening ahead of you.

Good luck

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