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The extraordinary case of the Guevedoces

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Catherine and his cousin Carla, Guevedoces in the Dominican Republic

Catherine and his cousin Carla, Guevedoces in the Dominican Republic

The discovery of a small community in the Dominican Republic, where some males are born looking like girls and only grow penises at puberty, has led to the development of a blockbuster drug that has helped millions of people, writes Michael Mosley.

Johnny lives in a small town in the Dominican Republic where he, and others like him, are known as “Guevedoces”, which effectively translates as “penis at twelve”.

We came across Johnny when we were filming for a new BBC Two series Countdown to Life, which looks at how we develop in the womb and how those changes, normal and abnormal, impact us later in life.

Like the other Guevedoces, Johnny was brought up as a girl because he had no visible testes or penis and what appeared to be a vagina. It is only when he approached puberty that his penis grew and testicles descended.

Johnny, once known as Felicita, remembers going to school in a little red dress, though he says he was never happy doing girl things.

“I never liked to dress as a girl and when they bought me toys for girls I never bothered playing with them – when I saw a group of boys I would stop to play ball with them.”

When he became obviously male he was taunted at school, and responded with his fists.

“They used to say I was a devil, nasty things, bad words and I had no choice but to fight them because they were crossing the line.”

We also filmed with Carla, who at the seven is on the brink of changing into Carlos. His mother has seen the change coming for quite a while.

“When she turned five I noticed that whenever she saw one of her male friends she wanted to fight with him. Her muscles and chest began growing. You could see she was going to be a boy. I love her however she is. Girl or boy, it makes no difference.”

Child on swing

 

 

So why does it happen? Well, one of the first people to study this unusual condition was Dr Julianne Imperato-McGinley, from Cornell Medical College in New York. In the 1970s she made her way to this remote part of the Dominican Republic, drawn by extraordinary reports of girls turning into boys.

When she got there she found the rumours were true. She did lots of studies on the Guevedoces (including what must have been rather painful biopsies of their testicles) before finally unravelling the mystery of what was going on.

When you are conceived you normally have a pair of X chromosomes if you are to become a girl and a set of XY chromosomes if you are destined to be male.

For the first weeks of life in womb you are neither, though in both sexes nipples start to grow.

Then, around eight weeks after conception, the sex hormones kick in. If you’re genetically male the Y chromosome instructs your gonads to become testicles and sends testosterone to a structure called the tubercle, where it is converted into a more potent hormone called dihydro-testosterone This in turn transforms the tubercle into a penis. If you’re female and you don’t make dihydro-testosterone then your tubercle becomes a clitoris.

Foetus at 12 weeks

When Imperato-McGinley investigated the Guevedoces she discovered the reason they don’t have male genitalia when they are born is because they are deficient in an enzyme called 5-alpha-reductase, which normally converts testosterone into dihydro-testosterone.

This deficiency seems to be a genetic condition, quite common in this part of the Dominican Republic, but vanishingly rare elsewhere. So the boys, despite having an XY chromosome, appear female when they are born. At puberty, like other boys, they get a second surge of testosterone. This time the body does respond and they sprout muscles, testes and a penis.

Imperato-McGinley’s thorough medical investigations showed that in most cases their new, male equipment seems to work fine and that most Guevedoces live out their lives as men, though some go through an operation and remain female.

Another thing that Imperato-McGinley discovered, which would have profound implications for many men around the world, was that the Guevedoces tend to have small prostates.

This observation, made in 1974, was picked up by Roy Vagelos, head of research at the multinational pharmaceutical giant, Merck. He thought this was extremely interesting and set in progress research which led to the development of what has become a best-selling drug, finasteride, which blocks the action of 5-alpha-reductase, mimicking the lack of dihydro-testosterone seen in the Guevedoces.

My wife, who is a GP, routinely prescribes finasteride as it is an effective way to treat benign enlargement of the prostate, a real curse for many men as they get older. Finasteride is also used to treat male pattern baldness.

A final interesting observation that Imperato-McGinley made was that these boys, despite being brought up as girls, almost all showed strong heterosexual preferences. She concluded in her seminal paper that hormones in the womb matter more than rearing when it comes to your sexual orientation.

This is still a controversial topic and one I explore later in the film when I meet Mati, who decided from the earliest age that though “he” looked like a boy, Mati was really a girl.

As for Johnny, since he developed male genitalia he has had a number of short term girlfriends, but he is still looking for love. “I’d like to get married and have children, a partner who will stand by me through good and bad,” he sighs wistfully.

Complete Article HERE!

Beginning Sex Play — Tips and Techniques

I most frequent hear from your average Dick and Jane, (or Dick and Dick, or Jane and Jane) who want to spice up their sex life. When they write to me they inevitably describe the kind of sex they’re currently having. And almost universally that description makes this grown man cry. Jeez, the boredom. How can they stand it? It’s a wonder any of them are having sex at all.

big funWhat’s with all the humdrum, run of the mill, we’ve always done it that way mentality? Are ya’ll afraid that if you add a little something new to your sex chore from time to time that the sky will fall? Holy cow!

Today’s tutorial is yet another attempt to motivate you to get off your butts and make something interesting happen in the sex department. We’ll begin today with what was once called foreplay.

First off, I hate the word “foreplay” because it suggests that all the really great sex play activities out there are only a lead up to a single — more important activity — that is fucking. It also implies that ya’ll can dispense with the one in order to hurry up and get to the other. And that, sex fans, is always a huge mistake.

From now on I want you to banish “foreplay” from your vocabulary. Instead let’s start using “Beginning Sex Play.” It says it all. It says it’s at the beginning, but there’s no suggestion that anything in particular must follow.amazing sex secrets

I’m of the mind that we’d all be better served if we thought of sex play as a continuum of pleasure with a beginning, middle and an end. If you ask me, our sex play ought mirror our sexual response cycles — arousal, plateau, orgasm and resolution. That way we’re less likely to overburden one particular activity at the expense of all the others. Get it? Got it? Good!

Experienced sex fans agree; the best sexual encounters include an extended period of sensual play at the beginning of most all sex play. This brings increased pleasure to both partners, and will make whatever else that might follow more satisfying. Just remember, beginning sex play can be a meal in itself.

Beginning sex play brings spice to the encounter because it gets our motors started. Even all you major sex athletes out there, who are perpetually primed for sex, will benefit from more beginning sex play. It will help cool your jets and make the encounter last longer than a firecracker. And I know that you know what I mean!

erotic talkIn our hectic rush-around-world, beginning sex play is particularly important. It helps us transition from the daily cares and woes to the realm of sensual pleasures. The workaholics among us need more time to become fully aroused. Our minds are still filled with the junk of the day, and not yet ready to give or receive pleasure. And pleasuring and being pleasured, I might add, takes a big attitude shift from that of the rest of the day. In fact, if you’re gonna try and approach sex and pleasure with the same mindset as you have on the job or with the kids, give it up now and be done with it. You’ll only walk away from the encounter disappointed.

Beginning sex play primes us for maximum pleasure. Us men folk will have the time we need to come to full erection and the women folk will have the time they need to properly lubricate. (By the way, this is called the arousal stage in our sexual response cycle).

When we stop thinking of beginning sex play as “foreplay” we realize there is no such thing as spending too much time giving and getting pleasure. If beginning sex play evolves into full-on fucking — SWELL. Both partners will be fully aroused and fucking will flow naturally and effortlessly from the pleasure enjoyed at the beginning of sex play.

Beginning sex play can include everything from chocolate and whipped cream to whips and chains. But let’s not get too far ahead of our selves. Let’s start at the beginning of beginning sex play, shall we? beginner's guide

Most people miss out on the pleasure of undressing with and for their partners. Stripping out of, or being helped out of our daily wear and into something sexy or nothing at all can be very arousing. It’s also a visual signal that we’re shifting out of our work-a-day world and entering the realm of sensuality. Stripping is an art form, ya know. We could all learn a lesson or two from the folks who do this for a living, but more about this in THIS tutorial.

Creating the right sex environment is important too. Make sure the room is warm. Proper lighting and music will surely add to the mood. Scents are also important. More and more people are incorporating erotica into their sex play — reading a sexy story together or enjoying some hot porn will make the encounter memorable.

Most women complain that their partners don’t kiss long enough and rush the kissing to get at their pussy. Guys, what the fuck? You want pussy? Use your mouth to maximum advantage kiss and nibble all over everything. Literally devour your partner with your mouth. Believe me, if you do this right, by the time you get to her pussy she’s gonna want to give it up big time.

Hanky Spanky Gift SetBeginning sex play is the perfect time for setting the mood for all that might follow. It’s a time for sharing fantasies, role-playing, dirty talk or some full body massage. Always have some nice lotion available then use your hands, forearms, feet and elbows to knead your partner’s muscles and naughty bits.

Certain areas on the body are more hot-wired than others. It’s your job to find each and every one your partner has. As you massage vary your strokes and touch to stimulate your partner. Roll your fingertips across his or her nipples and behind his or her ears as you kiss him and tease her with your tongue.

If you’re doin things right, your partner will be moaning with pleasure. If she or he starts getting impatient it’s time to bring out the restraints. There’s nothing like some hot erotic bondage to punctuate the beginning sex play.

While your darling is subdued and possibly blindfolded, crank things up a notch. Add different sensations and stimuli, a warm chocolate sauce followed by ice cream. A fur mitt followed by a Loofah. Introduce some sex toys — a vibrator, tit clamps, or an anal simulator.

Don’t forget to check in with your partner from time to time. Ask for some feedback and direction. Do you like this? Or do you like this better? If you presume that you know what your partner likes simply because he or she liked it before, that, my friend, is a recipe for boredom and the dreaded bed death. If words fail you, SHOW your partner what you want. Then encourage your partner to do the same.002

Beginning sex play is not about pressing the right buttons in the right order. It is about understanding what makes your partner tick and supplying and applying those things to their greatest sensual advantage. There are many ways to give your partner extreme pleasure, and it all begins in your brain. Beginning sex play is as much of an art form as it is a necessity. Finally, the basic premise behind all of this is that the great lover is one that gives pleasure because it is its own reward, not a means to getting something else.

Good luck

A Boy’s Own Story

What follows is an exchange I had recently with a young Catholic Canadian man.

Hi Dr. Wagner

My Name is Jack, I am a catholic teenager who is wondering if the act of masturbation is still considered to be a sin. Also is it really considered to be gravely disordered and always morally wrong? I am 18 years old and I am somewhat late going through changes physically. I do believe that it is a natural way to find out about ones body and how it can be used. I have heard that it is not a sin but a natural and healthy thing to do. I have also heard that it is a sin. I have heard mixed reviews I have heard that a vast majority of both boys and girls do it. I can understand if one does it while thinking about other people then it is a sin but if one is doing it to get rid of old stuff then does it count as a sin. I have done it recently and I am going through puberty. There are no thoughts, images or fantasies involved. I do think that it is better then having a nocturnal emission and having to clean your underpants and to hide it so no one think that I wet the bed. I also believe that it is better to masturbate rather than waking up to find a sticky mess in my underpants, which has happened to me, and it was not fun. I don’t want to have to go to bed worrying about a mess in the morning. I have also heard that it can help reduce the risk of prostate cancer. Is it normal to feel confused about it after doing it? I am planning to talk to my parents and a priest to see what they think of it. If my parents say that it is natural and a normal thing to do does that mean it is all right to do. The only tricky thing is that I am not entirely sure how to approach the subject with them. I have mentioned it to my mother and she doesn’t seem to be bothered by it. She said that it is better to do that than to be out having intercourse with girls. I haven t done it in 3 weeks and I feel conflicted over it I see both views on the issue and I am not sure. I don’t want to feel guilty for doing something that has been labeled natural and normal. I love and believe in god and want to know what the views are on it. I do not have any addiction whatsoever I have very good control over myself nor do I need counseling or therapy. I am just a curious teenager wondering if masturbating is a sin or not.

I live in Ontario where the ministry of education has released a updated sexual education curriculum where it mentions that masturbation is natural and normal. There is a part of me that really wants to do it as I feel it takes the edge off. I have heard that some catholic organizations are backing it. This leaves me confused if it is still considered to be a sin. I also believe that it is a crucial part of understanding how ones body works and learning about oneself. I do find it a little hard to understand that we can somewhat accept the sexual orientation of people but people still consider touching ones genitals to be a sin.

Thank you
God Bless

Dear Jack,

Thanks for your question. Might I add, you are exceptionally articulate for a teenager.a boy's own story

If ya ask me, Jack, and you are actually asking me, you’ve pretty much answered all of your own questions. And that tells me you are on the right track.

You ask about Catholic sexual ethics. Before you wrote, did you know that I was a Catholic priest for 20 years? And, not to boast, I am the only Catholic priest in the world with a doctorate in human sexuality. This later part explains why I no longer practice as a public minister. It’s a real long story and I’d be happy to tell you all about it sometime, but for now know that I didn’t go quietly. I wrote my doctoral thesis, Gay Catholic Priests; A Study of Cognitive and Affective Dissonance, back in 1981. And once word got out about this groundbreaking research, the writing was on the wall, so to speak, for my public ministry. I fought for my priesthood and ministry for 13 year, but it all pretty much came crashing in on itself in 1994. If you’ve got nothing better to do, you can read about it HERE.

Enough about me, let’s get back to you and your questions. Although, I wanted to mention that when I was in seminary, way back when god was young, in the late 1960’s and early 70’s, enlightened spiritual directors were already beginning to advise us seminarians that masturbation wasn’t sinful or disordered. Of course, even now you’ll find orthodox hard-liners who insist that self-pleasuring is a moral sin, but they think all sexual expression is sinful. Here’s a tip: you’re never gonna find consensus on any sexual matter.

Like you, I found it difficult to believe all that mortal sin stuff that the hardliners promote. I mean, if mass murder and genocide are mortal sins, how could a little wank be their equal. It just don’t make no sense, right?

However, I can’t agree with you that masturbation might be sinful if there are fantasies involved. Remember, using your mind is an essential part of learning about your sexuality. That being said, most teenage boys are randy at the drop of a hat, so maybe you don’t need to be all that specific with your sexual mental imagery.

I also caution you to be careful when tossing around words like normal and natural. What’s normal and natural to some may be abnormal and twisted to others. But you’re right; few people, professional as well as lay people, these days would consider self-loving anything but normal and natural.

For you edification I suggest you use the search function or CATEGORY pull-down menu in the sidebar of my site and search for pertinent topics, like masturbation, wet dreams, sexual response cycle, etc. You’ll find a wealth of information about all these topics in both written and podcast form.

the shadowI too reported, back in 2011, on the startling new data that came out of Australia about masturbation. Australian researchers questioned over 1,000 men who had developed prostate cancer and 1,250 men who had not, about their sexual habits. They found those who had ejaculated the most between the ages of 20 and 50 were the least likely to develop prostate cancer. The protective effect of poppin’ one’s nut was greatest while the men were in their 20s. And get this; men who ejaculated more than five times a week were a third less likely to develop prostate cancer later in life.

I also contend that masturbation is the most basic building block to all of our sexual expression. When you know how your body works; when you are familiar with your sexual response cycle and are confident about talking to others about it; you’ll be better situated to be a good sexual partner to another.

In the end, I encourage you to continue to think for yourself when it comes to things sexual. I can see that you are already doing that, so keep it up. Continue to ask questions and consider the input you get from others, myself included; but then make up your own mind. When you own your sexuality and your sexual response, you’ll be a grown-up. Notice I didn’t say you’d be an adult. That’s because there are lots of adults out there who don’t own their sexuality and sexual response and despite being grown up, they’re not grownups.

Good luck, pup

Hi Richard,
Thank you for responding. You have cleared come of the confusion. I guess I got confused because when I would masturbate I would feel like I let my self down.
Thank you again
God Bless

One thing you should know is there is generally a sort of “let down” phase after orgasm. (See information about the refractory phase of the sexual response cycle HERE.) Your body can’t stay in that heightened state of arousal so there’s often a “deflated” feeling.

There’s even a name for if. It’s called post-coital tristesse. And you should know that it’s a physiological phenomenon rather than an emotional one.

Feelings of elation and wellbeing that accompany arousal and orgasm can sometimes morph into a sense of shame during this “deflated” phase. People with lot of scruples about sex are particularly vulnerable to this.

Thank you for clearing that up and for the reassurance that it is natural and normal and not considered to be a sin.
— Jack

Another Selfish Asshole

Name: Samuel
Gender: Male
Age: 36
Location: Arkansas
Eight years ago I was involved with a woman who liked to fuck me in the ass with a strap-on. I liked it a lot, and when we stopped seeing each other, I missed the sensation. I’ve tried hooking up with other women who want to do this to me, but I’ve only found a few. And all of them were looking for a relationship, something I don’t want. Eventually I turned to men for the anal action I was missing. Some of guys are gay, some bi, and some straight. We never hug, kiss or do oral. I only receive, never give. I don’t see a guy for more than a couple of times. Now there seems to be fewer guys out there who want a tight ass to fuck. I prefer women, but men will do — I just really get off on the sensation.

Well, aren’t you a charming fucker…I mean fuckee. You don’t have a clue about how selfish you’re being, do you? And you’re wondering why the pool of people willing to pound your “tight ass” is drying up. It’s not the lack of fuckers out there. darlin’; it’s you!asshole

Listen; there are some basics that you seem to have overlooked when it comes to partnered sex. First among these is ya need at least a modicum of mutuality in your sex play. Did you ever hear of “Give to Get?” There’s probably no mystery why the first woman who strapped one on for you fled the scene. She discovered that you’re just in this for yourself. The other women who pegged you did so hoping they’d get something in return. Even the guys are fleeing in droves. And it’s entirely your fault, Sam. And ya know what else? I’d be willing to bet that you’re getting a reputation for yourself there in Arkansas. Nobody likes a self-absorbed prick. And that kind of bad rep gets around fast, especially in the hinterlands.

ill-stop-being-sarcasticAnyone wanting to get laid as much as you ought to learn how to finesse the fuck he wants. Lets start with the women. Most women are unaccustomed to being a top. Many would feel pretty self-conscious with a strap-on. In exchange for the kind of extraordinary sex you are looking for, most women would want something in return. Most would feel more comfortable exercising a kink in a relationship of some sort or another. They have little to gain otherwise. And if your behaviors with men are any indication of the sex you have with women, it’s surprising that you’ve got pegged at all.

Most men are a lot like most women in this regard. While there are a few of us men folk who will fuck whatever presents itself; even they will look for something in return besides a self-proclaimed tight ass to fuck. And here’s a tip — most guys who crow about how tight their ass is, are deluding themselves. Your insatiable hole is probably not in as pristine condition as you’d like to think.

I have several suggestions for you. First and foremost, treat your partners, even your casual hook ups, with some dignity and respect. Each one is more than just a stiff dick (or dildo) for you to pleasure yourself with. If you want to prevent the pool of available fuckers from evaporating completely, show some humanity yourself. Find out what turns your partner’s crank and get her/him warmed up for the fuck fest. If it take some hugging, kissing and a decent blowjob…you’d better take care of business. It’s the least you can do.

Finally, if you have a preference for women (and you’re put off by the idea of hugging, kissing and a blowin’ some dude just to get your sorry ass fucked); then rethink your aversion to having a relationship. There are all kinds of relationships — from fuck (pegging) buddies to marriage. Surly, you could find it in your heart to reward the woman willing to plug your hungry ass with a little something more than “catch ya later, bitch!”

Good luck

What does is all mean?

Name: Jane
Gender: Female
Age: 23
Location: Vancouver. BC
When my boyfriend and I have sex, there’s a 50/50 chance that he will put his penis between my butt cheeks and hump me that way until he cums. (It’s just intense rubbing, no anal penetration). Even though I don’t feel like I’m getting any pleasure from it, my vagina gets wet, and if he touches me down there and feels that I’m wet, it turns him on even more. What’s going on here?
He’s very affectionate and he tells me he loves by my body. He says he’s totally straight, but this whole anal thing confuses me. If he’s not gay or bi-sexual, why is it that it takes him 20+ minutes to cum during vaginal sex, but only 5 – 7 minutes to cum during anal?

Ok, Jane, to start with, your BF isn’t doing anal. Believe me, darling, you’d know if he were. Anal sex, by definition, means anal penetration. There’s a name for what your freaky boyfriend is doing — rubbing his cock in your crack, but not penetrating you. It’s a form of frottage, or sexual stimulation by rubbing. This is the sexual practice of choice for most lesbians, most commonly referred to as pussy-bumpin’. Hey, maybe your BF is a lesbian!analsex joke

Second, your pussy may be getting wet because your boyfriend’s pre-cum and spooge is dripping down your crack, past your “taint” and all over your fine cooch. It ain’t you producing the wetness, which explains why you’re not aroused. I hope that clears up the mystery juice for ya.

Third, loads of exclusively straight men are into anal. Most are into butt fucking their women, but some are into being fucked BY their women. We call this practice pegging — a woman straps on a mighty fine dildo and drives her man insane with a buggering he’ll not soon forget. So you see, fucking is not just for cunts anymore!

Forth, perhaps, just maybe, your vagina isn’t as tight as your what your man is experiencing between your ass cheeks. Maybe, just perhaps, that’s why it takes him less time to bust a nut that-a-way than in a more traditional form of fucking. Also maybe, he’s more turned on with the allure of the forbidden, taboo backdoor action. I guess the only way you’ll know is to ask your BF straight-up, as it were, so to speak.

So let’s review then, shall we? Now that we know for certain that an interest in cornholing a sweet ass is not just a gay thing. You can relax about your BF bein’ queer for wanting to hump your bum. For some guys this is their favorite kind of sex. They love to bust a nut by rubbing their dicks between a chick’s tits, thighs, buns, or feet. It’s anyone’s guess why these dudes prefer this to getting off in, on or around a pussy, but whatever it is, it’s completely harmless.Anal sex

Here’s a tip, Jane. Relax into this with the ‘ol BF, why don’t ya? Once you stop worrying about his sexual orientation because of his fascination with your be-hind, you may actually enjoy the special attention he’s paying your boot-ty.

And hey, if your BF’s freak with your ass crack isn’t gettin’ you off, you don’t have to just lie there and take it, ya know. While he’s grinding away back there, you could be spending some quality time with little miss clit with say a swell vibrator. Soon you’ll be enjoying things as much as he.

Good luck

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